HIV and Ageing
Simon Briggs
Outline
Introduction
HIV infection and premature ageing
What may contribute to premature ageing?
Reducing chronic inflammation related to HIV
infection
What we can do to slow the premature ageing
process?
Introduction
The development of
antiretroviral
treatment (ART) is
one of the greatest
advances in modern
medicine
ART has changed HIV
infection from a lethal
disease to a chronic
manageable illness
Percentage yearly mortality for
patients with HIV infection ACH
Percentage
Year
AZT or ddI
AZT and ddI
AZT, ddI and saquinavir
Current estimates are that someone
diagnosed with HIV infection today should live
for almost as long as someone without HIV
infection
Life expectancy estimates at age 20
years BMC Infect Dis 2015;15:274
Despite the remarkable success of ART, it does
not fully restore health
Many people living with HIV infection seem to
age more quickly than those without HIV
infection
HIV infection and premature ageing
The slightly shorter lifespan is largely due to an
increased risk of “non-AIDS” complications
heart disease
liver disease
kidney disease
neurological conditions
some cancers
frailty
Many of these complications are similar to those
experienced by the elderly or those with other
chronic diseases such as diabetes